The Single Best Strategy To Use For ceesdekker.net
The Single Best Strategy To Use For ceesdekker.net
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Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we seek out to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate passions incorporate:
1996, first mesoscopic cost density waves equipment; and initial electrical measurements on an individual metallic nanocluster in between nanoelectrodes
‘It absolutely was only a subject of finding up a e-book on cell biology and beginning to go through. I had originate from a planet of ultra-significant vacuums, cryostats and quantum phenomena, and now I used to be Operating at space temperature with molecular biology kits.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
That is a aspiration of mine and we established to work by using a delectable dose of naivety. This can be a thing that will most likely yield stunning brings about the for a longer time time period, but that does not issue. You shouldn't only want to operate around the inquiries of tomorrow, but will also around the queries with the working day following tomorrow.’
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
What distinguishes biology from chemistry is always that these components jointly make up a living technique. The secret of explained life, I feel, lies in the interactions, ceesdekker the interplay of Those people molecules. The large problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from simple molecules to the exceptionally sophisticated units we see these days? We do not know. I want to work on These types of significant, open inquiries.’
Learning DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
The rotors harness Power from the nanoscale drinking water and ion flow that is created by a static chemical or electrochemical likely gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological situations, suggesting ways to setting up Power-transducing motors at nanoscale interfaces.
Bulk-area coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared top-down in People times and identified about five hundred genes which have been minimally necessary for just a functioning cell. We wish to look bottom-up: how do we go from the handful of molecules to a whole Organic system?
Enable’s first appear back in the intervening time after you made a decision to change your aim from superconductivity and nanotubes to biology at the conclusion of the nineteen nineties.
2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental examine of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization of your mechanical Homes of double-stranded RNA; and initial one-molecule research of DNA translocation by a restriction-modification enzyme.